If you’re using Keynote and want to disable “snapping” to objects or the grid, this is what you need.
Basically, you can turn those off in the preferences, in Ruler Preferences.
Also, if you don’t want to completely turn off the guides so that you can use them while aligning larger groups or other objects, holding down the “Command” or “Apple” key will make the object you’re currently dragging not snap to anything.